Materials and Methods: The study included 110 neonates classified into four groups according the total bilirubin (TB) levels: G1 (n=31 TB 5 and 10 and 15 mg/dl). In this study relationship between the levels of serum bilirubin and malondialdehyde was investigated in neonates with different stages of hyperbilirubinaemia. Malondialdehyde (MDA) is a metabolite commonly used as indicator of free radical generation by lipid peroxidation. Increase of bilirubin production could be a response to an initial oxidative stress.Serum MDA levels in the neonate could be used as an indicator or predictorof the severity of neonatal jaundice. That may indicate the possible protective effect of antioxidant administration to the mother during pregnancy on the neonate. Conclusions: The increases of serum total bilirubin levels in the neonate could be a response to excessive free radical generation and lipid peroxide formation. A significant negative correlation was found between malondialdehyde and haemoglobin (P<0.001) in the same groups.
![]() Serum Terbaru Free Radical Generation
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